KMID : 0387420050160010097
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Korean Society of Oriental Neuropsychiatry 2005 Volume.16 No. 1 p.97 ~ p.117
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The Effects of Chaenomelis fructus,(CMF) Extract on the Alzheimer¡¯s Disease Model Induced by CT-105 and ${\beta}A$
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Kim Myung-Jin
Jung In-Chul Lee Sang-Ryong
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Abstract
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This research investigates the effect of the Chaenomelis fructus(CMF) on Alzheimer¡¯s disease. Specifically, the effects of the CMF extract on (1) >$IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CT-105; (3) the AChE activity and the APP production of PC-12 cell treated with CT-105; (4) the behavior of AD mice with ${\beta}A$; (5) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and ROS; (6) the infarction area of the hippocampus, and brain tissue injury in Alzheimer¡¯s diseased mice induced with ${\beta}A$ were investigated. The results were summarized as follows; 1. The CMF extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-1 cells treated with LPS. 2. The CMF extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The CMF extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. A significant inhibitory effect on the memory deficit was shown on the CMF extract group of the mice with Alzheimer¡¯s disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The CMF extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, $IL-1{\beta}$ protein, mRNA, $TNF-{\alpha}$ mRNA, CD68/GFAP, and ROS in the mice with Alzheimer¡¯s disease induced by ${\beta}A$. 6. The CMF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer¡¯s disease induced by ${\beta}A$. These results suggest that the CMF extract may be effective for the treatment of Alzheimer¡¯s disease. Investigation into the clinical use of the CMF extract for Alzheimer¡¯s disease is suggested for future research.
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KEYWORD
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Chaenomelis fructus, Alzheimer¡¯s Disease
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